As the nuclear industry is looking to increase light water reactor (LWR) burnup limits, Idaho National Laboratory has developed an experiment vehicle for the Transient Reactor Test Facility (TREAT) to support high burnup fuel safety testing. One of the main purposes of this vehicle, known as the Transient Water Irradiation System for TREAT (TWIST), is to perform in-pile loss-of-coolant accident (LOCA) experiments on high burnup LWR fuel to investigate phenomena termed fuel fragmentation, relocation, and dispersal (FFRD). Prior to performing experiments on high burnup fuel specimens, a commissioning test series will be performed. The main purpose of the Loss-of-Coolant-Commissioning (LOC-C) test series is to qualify the TWIST device and validate the power coupling between TREAT and the TWIST fuel rod as well as validation of the thermal-hydraulic and fuel performance simulation predictions.